Publications

Click here to see a list of Dr. Jepsen's publications on PubMed.

BASIC RESEARCH

  1. Bonadio J, Jepsen KJ, Mansoura MK, Jaenisch R, Kuhn JL, and Goldstein SA. A murine skeletal adaptation that significantly increases cortical bone mechanical properties - Implications for human skeletal fragility. Journal of Clinical Investigation, 92:1697-1705, 1993.
  2. Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type I collagen mutation compromises the post-yield behavior of Mov13 long bone. Journal of Orthopaedic Research, 14:493-499, 1996.
  3. Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RG, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. Journal of Biomechanics, 30(11/12):1141-1147, 1997.
  4. Jepsen, K.J., Pennington, D.E., Lee, Y.-L., Warman, M., Nadeau, J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res, 16(10):1854-1862, 2001.
  5. Jepsen KJ, Akkus O, Majeska RJ, Nadeau JH. Hierarchical relationship between genetically determined bone traits and whole bone mechanical properties in inbred mice. Mammalian Genome, 14(2):97-104, 2003.
  6. Tommasini SM, Morgan TG, van der Meulen MCH, Jepsen KJ. Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body. Journal of Bone and Mineral Research, 20(5):817-827, 2005.
  7. Price C, Herman BC, Lufkin T, Goldman HM, Jepsen KJ. Genetic variation in bone growth patterns defines adult mouse bone fragility. Journal of Bone and Mineral Research, 20(11): 1983-1991, 2005.
  8. Jepsen KJ, Hu B, Tommasini SM, Courtland H-W, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mammalian Genome, 18(6-7):492-507, 2007. PMC1998883
  9. Tommasini SM, Wearne SL, Hof PR, Jepsen KJ. Percolation theory relates corticocancellous architecture to mechanical function in vertebrae of inbred mouse strains. Bone; 42(4), 2008. PMC2650241
  10. Courtland H-W, Nasser P, Goldstone AB, Spevak L, Boskey AL, Jepsen KJ. FTIRI microspectroscopy and micromechanical testing reveal intra-species variation in mouse bone mineral composition and matrix maturity. Calcified Tissue International, 83(5):342-353, 2008. PMC2650490
  11. Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae. J Bone Miner Res, 24:606-620, 2009. PMC2659510
  12. Jepsen KJ, Hu B, Tommasini SM, Courtland H-W, Price C, Cordova M, Nadeau JH. Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains. Mammalian Genome, 20(1):21-33, 2009. PMC2650248
  13. Jepsen KJ, Courtland H-W, Nadeau JH. Genetically-determined phenotype covariation networks control bone strength. J Bone Miner Res, 25:1581-1593, 2010. PMID 20200935 (PMC3153133)
  14. Smith, L., Bigelow, E. M., Jepsen, K. J. Systematic evaluation of skeletal mechanical function. Current protocols in mouse biology, 39-67, 2013.
  15. Smith, L. M., Bigelow, E. M., Nolan, B. T., Faillace, M. E., Nadeau, J. H., Jepsen, K. J. Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice. Bone, 67, 130-138, 2014.
  16. Khoury BM, Bigelow EMR, Smith LM, Schlecht SH, Scheller EL, Andarawis-Puri N, Jepsen KJ. The use of nano-computed tomography to enhance musculoskeletal research. Conn Tissue Res; 2014; early view, doi:10.3109/03008207.2015.1005211.

TRANSLATIONAL RESEARCH

  1. Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. The relationship between bone morphology and bone quality in male tibiae: Implications for stress fracture risk. Journal of Bone and Mineral Research, 20(8):1372-1380, 2005.
  2. Tommasini SM, Nasser P, Jepsen KJ. Sexual dimorphism affects tibial size and shape but not tissue-level mechanical properties. Bone, Bone, 40, 498-505, 2007.
  3. Tommasini SM, Nasser P, Hu B, Jepsen KJ. Biological co-adaptation of morphological and compositional traits contributes to mechanical functionality and skeletal fragility. Journal of Bone and Mineral Research, 23(2):236-246, 2008. PMC2665697
  4. Jepsen KJ. Systems analysis of bone. Invited review, Wiley Interdisciplinary Reviews: Systems Biology and Medicine 1(1):73-88, 2009. PMC2790199
  5. Pandey N, Bhola S, Goldstone A, Chen F, Chrzanowski J, Terranova CJ, Ghillani R, Jepsen KJ. Inter-individual variation in functionally adapted trait sets is established during post-natal growth and predictable based on bone robusticity. J Bone Miner Res, 24(12):1969-1980, 2009. PMC2791514
  6. Jepsen KJ, Centi A, Duarte GF, Galloway K, Goldman H, Hampson N, Lappe JM, Cullen DM, Greeves J, Izard R, Nindl BC, Kraemer WJ, Negus CH, Evans RK. Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults. Journal of Bone and Mineral Research, 26:2872-2885, 2011. PMID 21898595 (PMC Journal - In Process).
  7. Andarawis-Puri N, Sereysky JB, Jepsen KJ, Flatow EL. The relationships between cyclic fatigue loading, changes In initial mechanical properties, and the in vivo temporal mechanical response of the rat patellar tendon. Journal of Biomechanics, 45(1):59-65, 2012. PMID 22055428
  8. Epelboym Y, Gendron RN, Mayer J, Fusco J, Nasser P, Gross G, Ghillani R, Jepsen KJ. The inter-individual variation in femoral neck width is associated with the acquisition of predictable sets of morphological and tissue-quality traits and differential bone loss patterns. Journal of Bone and Mineral Research, 27(7):1501-1510, 2012. PMID 22461103 (PMC Journal - In Process)
  9. Jepsen KJ, Evans R, Negus CH, Gagnier JJ, Centi A, Erlich T, Hadid A, Yanovich R, Moran DS. Variation in tibial functionality and fracture susceptibility among healthy, young adults arises from the acquisition of biologically distinct sets of traits. Journal of Bone and Mineral Research, in press, 2013.
  10. Schlecht SH, Jepsen KJ. Functional integration of skeletal traits: an intraskeletal assessment of bone size, mineralization and volume covariance. Bone, submitted Feb 2013
  11. Jepsen KJ, Schlecht SH, Kozloff KM. Are we taking full advantage of the growing number of pharmacological treatment options for osteoporosis? Current Opinion in Pharmacology 16:64-71, 2014.
  12. Jepsen KJ, Schlecht SH. Biomechanical mechanisms: resolving the apparent conundrum of why individuals with type II diabetes show increased fracture incidence despite having normal BMD. Journal of Bone and Mineral Research 29:784-786, 2014.
  13. Schlecht SH, Bigelow EMR, Jepsen KJ. Mapping the natural variation in whole bone stiffness across skeletal sites. Bone; 2014; 67:15-22.
  14. Khoury BM, Bigelow EMR, Smith LM, Schlecht SH, Scheller EL, Andarawis-Puri N, Jepsen KJ. The use of nano-computed tomography to enhance musculoskeletal research. Conn Tissue Res; 2014; early view, doi:10.3109/03008207.2015.1005211.
  15. Jepsen KJ, Bigelow EMR, Schlecht SH. Women build long bones with less cortical mass relative to body size and bone size compared with men. Clin Orthop Rel Res; 2015; early view, doi:10.1007/s11999-015-4184-2.
  16. Schlecht SH, Bigelow EMR, Jepsen KJ. How does bone strength compare across sex, site, and ethnicity?. Clin Orthop Rel Res; 2015; early view, doi:10.1007/s11999-015-4229-6.

COMPLETE LIST

  1. Hollister SJ, Fyhrie DP, Jepsen KJ, and Goldstein SA. Application of homogenization theory to the study of trabecular bone mechanics. Journal of Biomechanics, 24(9):825-839, 1991.
  2. Bonadio J, Jepsen KJ, Mansoura MK, Jaenisch R, Kuhn JL, and Goldstein SA. A murine skeletal adaptation that significantly increases cortical bone mechanical properties - Implications for human skeletal fragility. Journal of Clinical Investigation, 92:1697-1705, 1993.
  3. Lewis DB, Liggitt DL, Effmann EL, Motley ST, Teitelbaum SL, Jepsen KJ, Goldstein SA, Bonadio J, Carpenter J, and Perlmutter RM. Osteoporosis induced in mice by overproduction of interleukin 4. Proceedings National Academy of Science, USA, 90:11618-11622, 1993.
  4. Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type I collagen mutation compromises the post-yield behavior of Mov13 long bone. Journal of Orthopaedic Research, 14:493-499, 1996.
  5. Jepsen KJ, Davy DT. Comparison of damage accumulation measures in human cortical bone. Journal of Biomechanics, 30(9):891-894, 1997.
  6. Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RG, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. Journal of Biomechanics, 30(11/12):1141-1147, 1997.
  7. Chakravarti, S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H. Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. Journal of Cell Biology, 141(5):1-10, 1998.
  8. Jepsen KJ, Davy DT, Krzypow DJ. The role of the lamellar interface during torsional yielding of human cortical bone. Journal of Biomechanics, 32(3):303-310, 1999.
  9. Dean D, Topham NS, Rimnac C, Mikos AG, Goldberg DP, Jepsen K, Redtfeldt R, Pennington D, Ratcheson R. Osseointegration of preformed polymethylmethacrylate craniofacial prostheses coated with bone marrow impregnated poly(DL-lactic-co-glycolic acid) foam. Plastic and Reconstructive Surgery, 104(3):705-712, 1999.
  10. Akkus, O, Jepsen, KJ, Rimnac, CM. Microstructural aspects of the fracture process in human cortical bone. Journal of Material Science, 35:6065-6074, 2000.
  11. Schaffler, MB and Jepsen, KJ. Fatigue and repair in bone. International Journal of Fatigue, 22:839-846, 2000.
  12. van der Meulen, MCH, Jepsen, KJ, Mikic, B. Understanding bone strength: Size isn't everything. Bone, 29(2):101-104, 2001.
  13. Jepsen, K.J., Pennington, D.E., Lee, Y.-L., Warman, M., Nadeau, J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res, 16(10):1854-1862, 2001.
  14. Ameye, L, Aria, D, Jepsen, K, Oldberg, A, Xu, T, Young, M. Abnormal collagen fibrils in tendons of biglycan/fibromodulin deficient mice lead to gait impairment, ectopic ossification and osteoarthritis. FASEB J, 16:673-680, 2002.
  15. Jepsen KJ, Wu F, Peragallo JH, Paul J, Roberts L, Ezura Y, Oldberg A, Birk DE, Chakravarti S. A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. Journal of Biological Chemistry, 277:35532-35540, 2002.
  16. Islam N, Haqqi TM, Jepsen KJ, Kraay M, Welter JF, Goldberg VM, Malemud CJ. Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53, c-myc, and bax-alpha and suppression of bcl-2. Journal of Cellular Biochemistry, 87:266-278, 2002.
  17. Jepsen KJ, Akkus O, Majeska RJ, Nadeau JH. Hierarchical relationship between genetically determined bone traits and whole bone mechanical properties in inbred mice. Mammalian Genome, 14(2):97-104, 2003.
  18. Akkus O, Knott DF, Jepsen KJ, Davy DT, Rimnac CM. Relationship between damage accumulation and mechanical property degradation in cortical bone: Microcrack orientation is important. J Biomed Mater Res, 65A(4):482-8, 2003.
  19. Angele P, Yoo JU, Smith C, Mansour J, Jepsen KJ, Nerlich M, Johnstone B. Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro. J Orthop Res. 2003 May;21(3):451-7.
  20. Dean D, Topham NS, Meneghetti SC, Wolfe MS, Jepsen K, He S, Chen JE, Fisher JP, Cooke M, Rimnac C, Mikos AG. Poly(propylene fumarate) and poly(DL-lactic-co-glycolic acid) as scaffold materials for solid and foam-coated composite tissue-engineered constructs for cranial reconstruction. Tissue Eng. 9(3):495-504, 2003.
  21. Jepsen KJ. The aging cortex: To crack or not to crack. Osteoporos Int. 2003 Sep;14 Suppl 5:57-66. 2003.
  22. Wiren KM, Zhang X-W, Toombs AR, Kasparcova V, Harada S-I, Jepsen KJ. Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals. Endocrinology, 145(7):3507-3522, 2004.
  23. Tanck E, Van Donkelaar CC, Jepsen KJ, Goldstein SA, Weinans H, Burger EH, Huiskes R. The mechanical consequences of mineralization in embryonic bone. Bone 35: 186-190, 2004.
  24. Churchill GA, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov;36(11):1133-7.
  25. Li CY, Delisser K, Nasser P, Laudier D, Clement M, Jepsen KJ, Schaffler MB, Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis. Journal of Bone and Mineral Research, 20(1):117-124, 2005.
  26. Tommasini SM, Morgan TG, van der Meulen MCH, Jepsen KJ. Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body. Journal of Bone and Mineral Research, 20(5):817-827, 2005.
  27. Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. The relationship between bone morphology and bone quality in male tibiae: Implications for stress fracture risk. Journal of Bone and Mineral Research, 20(8):1372-1380, 2005.
  28. Price C, Herman BC, Lufkin T, Goldman HM, Jepsen KJ. Genetic variation in bone growth patterns defines adult mouse bone fragility. Journal of Bone and Mineral Research, 20(11): 1983-1991, 2005.
  29. Li CY, Schaffler MB, Wolde-Semait H, Hernandez CJ, Jepsen KJ. Genetic background influences cortical bone response to ovariectomy. Journal of Bone and Mineral Research, 20(12): 2150-2158, 2005.
  30. Gerstenfeld LC, Alkhiary YM, Krall EA, Nicholls FH, Stapleton SN, Fitch JL, Bauer M, Kayal R, Graves DT, Jepsen KJ, Einhorn TA, Three dimensional reconstruction of fracture callus morphogenesis demonstrate asymmetry in callus development. The Journal of Histochemical and Cytochemistry, 54(11):1215-28, 2006.
  31. Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB. Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite osteosclerosis. Journal of Bone and Mineral Research, 21(6):865-875, 2006.
  32. Wang VM, Banack TM, Tsai CW, Flatow EL, Jepsen KJ. Variability in tendon and knee joint biomechanics among inbred mouse strains. Journal of Orthopaedic Research, 24(6):1200-1207, 2006.
  33. Tommasini SM, Nasser P, Jepsen KJ. Sexual dimorphism affects tibial size and shape but not tissue-level mechanical properties. Bone, Bone, 40, 498-505, 2007.
  34. Jepsen KJ, Hu B, Tommasini SM, Courtland H-W, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mammalian Genome, 18(6-7):492-507, 2007. PMC1998883
  35. Joo W, Jepsen KJ, Davy DT. The effect of recovery time and test conditions on viscoelastic measures of tensile damage in cortical bone. Journal of Biomechanics, 40(12):2731-2737, 2007. PMC2711772
  36. Tommasini SM, Nasser P, Hu B, Jepsen KJ. Biological co-adaptation of morphological and compositional traits contributes to mechanical functionality and skeletal fragility. Journal of Bone and Mineral Research, 23(2):236-246, 2008. PMC2665697
  37. Tommasini SM, Wearne SL, Hof PR, Jepsen KJ. Percolation theory relates corticocancellous architecture to mechanical function in vertebrae of inbred mouse strains. Bone; 42(4), 2008. PMC2650241
  38. Jepsen KJ, Price C, Silkman LJ, Nicholls FH, Nasser P, Hu B, Hadi N, Alapatt M, Stapleton SN, Kakar S, Einhorn TA, Gerstenfeld LC. Genetic variation in the patterns of skeletal stem cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. Journal of Bone and Mineral Research, 23 (8):1204-1216, 2008. PMC2650253
  39. Wiren KM, Semirale A, Zhang X-W, Woo A, Tommasini SM, Price C, Schaffler M, Jepsen KJ. Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis. A model for compartment-specific androgen action in the skeleton. Bone, 43(3):440-451, 2008. PMC2574646
  40. Courtland H-W, Nasser P, Goldstone AB, Spevak L, Boskey AL, Jepsen KJ. FTIRI microspectroscopy and micromechanical testing reveal intra-species variation in mouse bone mineral composition and matrix maturity. Calcified Tissue International, 83(5):342-353, 2008. PMC2650490
  41. Jepsen KJ. Systems analysis of bone. Invited review, Wiley Interdisciplinary Reviews: Systems Biology and Medicine 1(1):73-88, 2009. PMC2790199
  42. Jepsen KJ. Genetic basis of skeletal functionality and fragility. Invited review, US Musculoskeletal Review, Volume 3, Issue 1. Touch Briefings publisher, 2008. PMC2650253
  43. Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae. J Bone Miner Res, 24:606-620, 2009. PMC2659510
  44. Jepsen KJ, Hu B, Tommasini SM, Courtland H-W, Price C, Cordova M, Nadeau JH. Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains. Mammalian Genome, 20(1):21-33, 2009. PMC2650248
  45. Fung DT, Wang VM, Laudier DM, Shine JH, Basta-Pljakic J, Jepsen KJ, Schaffler MB, Flatow EL. Subrupture tendon fatigue damage. J Orthop Res, 27:264-273, 2008.
  46. Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D. The MKR mouse model of Type 2 diabetes demonstrates slender bones and increased fragility secondary to increased osteoclastogenesis. Bone, 44(4):648-655, 2009. PMC2659558
  47. Courtland H-W, Spevak L, Boskey AL, Jepsen KJ. Genetic variation in mouse femoral tissue-level mineral content underlies differences in whole bone mechanical properties. Cells Tissues Organs 189:237-240, 2009.
  48. Pandey N, Bhola S, Goldstone A, Chen F, Chrzanowski J, Terranova CJ, Ghillani R, Jepsen KJ. Inter-individual variation in functionally adapted trait sets is established during post-natal growth and predictable based on bone robusticity. J Bone Miner Res, 24(12):1969-1980, 2009. PMC2791514
  49. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Hector J, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of IGF-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J, 23(3):709-719, 2009. PMC2653987
  50. Shao H, Burrage L, Sinasac D, Hill A, Ernest S, O'Brien W, Courtland H-W, Jepsen K, Kirby A, Kulbokas EJ, Daly M, Broman K, Lander E, Nadeau J. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. PNAS, 105(50):19910-19914, 2008. PMC2604967
  51. Lichtblau S, Gallina J, Nasser P, Munyoki M, Jepsen K. A biomechanical comparison of two patterns of screw insertion. Bulletin of the NYU Hospital for Joint Diseases, 66:269-271, 2008.
  52. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland H-W, Williams V, Bouxsein M, Rosen R, Jepsen KJ. Serum IGF-1 determines skeletal strength by regulating sub-periosteal expansion and compensatory trait interactions. J Bone Miner Res, 24:1481-1492, 2009. PMC2718800
  53. Pinto M, Jepsen KJ, Terranova CJ, Buffenstein R. Lack of sexual dimorphism in femora of the eusocial and hypogonadic naked mole-rat; a novel animal model for the study of delayed puberty on the skeletal system. Bone, 46:112-120, 2010. (NIHMS146045)
  54. Jepsen KJ, Courtland H-W, Nadeau JH. Genetically-determined phenotype covariation networks control bone strength. J Bone Miner Res, 25:1581-1593, 2010. PMID 20200935 (PMC3153133)
  55. Fung DT, Wang VM, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech, 19:274-279, 2010.
  56. Emerton KB, Hu B, Woo AA, Sinofsky A, Hernandez C, Majeska RJ, Jepsen KJ, Schaffler MB. Osteocyte apoptosis and control of bone resorption following ovariectomy in mice. Bone, 46:577-583, 2010. PMC2824001
  57. Simonaro CM, Ge Y, Eliyahu E, He X, Jepsen KJ, Schuchman EH. Inflammation in the mucopolysaccharidoses: Involvement of the toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment. Proceedings National Academy of Sciences, 107:222-27, 2009. PMC2806747
  58. Nowlan NC, Jepsen KJ, Morgan EF. Smaller, weaker and less stiff bones evolve from changes in subsistance strategy. Osteoporosis International, 22(6):1967-80 2011. PMID 20857281 (PMC Journal - In Process)
  59. Fung DT, Basta-Pljakic, Sereysky JB, Laudier DM, Huq R, Jepsen KJ, Schaffler MB, Flatow EL. Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons. Ann Biomed Eng, 38:1741-1751, 2010. PMID 20232150 (PMC Journal - In Process)
  60. Sun HB, Li Y, Fung D, Lee JY, Wang VM, Basta-Pljakic J, Klug RA, Ramcharan M, Braman J, Laudier DM, Andarawis-Puri N, Jepsen KJ, Schaffler MB, Flatow EL. Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. J Orthop Res, 28(10):1380-1386, 2010. PMID 20857281 (PMC Journal - In Process)
  61. Sereysky JB, Andarawis-Puri N, Ros SJ, Jepsen KJ, Flatow EL. Automated image analysis method for quantifying damage accumulation in tendon. J Biomech, 43(13):2641-2644, 2010. PMID 20627302 (PMC Journal - In Process)
  62. Jepsen KJ. Functional interactions among morphological and tissue-quality traits define bone quality. Invited review. Clin Orthop Rel Research, 469(8):2150-2159, 2011. PMID 21125361 (PMC3126971)
  63. Gerstenfeld LC, McLean J, Healey DS, Stapleton SN, Silkman LJ, Price C, Jepsen KJ. Genetic variation in the structural pattern of osteoclast activity during post-natal growth of mouse femora, Bone, 46:1546-1554, 2010. PMID 20178867 (PMC Journal - In Process)
  64. Elis S, Courtland H-W, Wu Y, Rosen CJ, Sun H, Jepsen KJ, Majeska RJ, Yakar S. Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. J Bone Mineral Res, 25:1257-1266, 2010. PMID 20200935 (PMC3153133)
  65. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R Guidelines for Assessment of Bone Microstructure in Rodents using Microcomputed Tomography. J Bone Miner Res, 25:1468-1486, 2010. PMID 20533309 (PMC Journal - In Process)
  66. Herman BC, Cardoso L, Majeska RJ, Jepsen KJ, Schaffler MB. Activation of bone remodelling after fatigue: Differential response to linear microcracks and diffuse damage. Bone, 47:766-772, 2010. PMID 20633708 (PMC2939191)
  67. Pathak S, Swadener JG, Kalidindi SR, Courtland H-W, Jepsen KJ, Goldman HM. Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation. Journal of the Mechanical Behavior of Biomedical Materials, 4:34-43, 2010. PMID 20857281 (NIHMS237962)
  68. Bhola S, Chen J, Fusco J, Duarte GF, Andarawis-Puri N, Ghillani R, Jepsen KJ, Variation in childhood skeletal robustness is an important determinant of cortical area in young adults. Bone, 49:799-809, 2011 PMID 21810492 (PMC3167032).
  69. Courtland HW, Elis S, Wu Y, Sun H, Rosen CJ, Jepsen KJ, Yakar S. Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner. PLoS One. March 18; 6(3):e14762. 2011 PMID 21483786 (PMC3060807)
  70. Izu Y, Sun M, Zwolanek D, Veit, Williams V, Cha B, Jepsen KJ, Koch M, Birk D. Type XII collagen regulates osteoblast polarity and communication during bone formation. Journal of Cell Biology, 193(6):1115-1130, 2011. PMID 21670218 (PMC3115787)
  71. Arteaga-Solis E, Sui-Arteaga L, Kim M, Schaffler MB, Jepsen KJ, Pleshko N, Ramirez F. Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biology, 30:188-194, 2011. PMID 21440062 (PMC3097426)
  72. Jepsen KJ, Centi A, Duarte GF, Galloway K, Goldman H, Hampson N, Lappe JM, Cullen DM, Greeves J, Izard R, Nindl BC, Kraemer WJ, Negus CH, Evans RK. Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults. Journal of Bone and Mineral Research, 26:2872-2885, 2011. PMID 21898595 (PMC Journal - In Process).
  73. Andarawis-Puri N, Sereysky JB, Jepsen KJ, Flatow EL. The relationships between cyclic fatigue loading, changes In initial mechanical properties, and the in vivo temporal mechanical response of the rat patellar tendon. Journal of Biomechanics, 45(1):59-65, 2012. PMID 22055428
  74. Eliyahu E, Wolfson T, Ge Y, Jepsen KJ, Schuchman EH, Simonaro CM. Anti-TNF-alpha therapy enhances the effects of enzyme replacement therapy in rats with mucopolysaccharidosis type VI. PLoS One, 6:e22447, 2011. PMID 21887218 (PMC3159569)
  75. Grimes R, Jepsen KJ, Fitch JL, Einhorn TA, Gerstenfeld LC. The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation. J Bone Miner Res 26:2597-2609, 2011. PMID 21826735 (PMC Journal - In Process)
  76. Andarawis-Puri N, Sereysky JB, Sun H, Jepsen KJ, Flatow EL. Molecular response of the patellar tendon to fatigue loading explained in the context of the initial induced damage and number of fatigue loading cycles. J Orthop Res, 30(8):1327-1334, 2012. PMID 22227881 (PMC Journal - In Process)
  77. Sereysky JB, Andarawis-Puri N, Jepsen KJ, Flatow EL. Structural and mechanical effects of in vivo fatigue damage induction on murine tendon. J Orthop Res, 30:965-972, 2012. PMID 22072573 (PMC Journal - In Process)
  78. Epelboym Y, Gendron RN, Mayer J, Fusco J, Nasser P, Gross G, Ghillani R, Jepsen KJ. The inter-individual variation in femoral neck width is associated with the acquisition of predictable sets of morphological and tissue-quality traits and differential bone loss patterns. Journal of Bone and Mineral Research, 27(7):1501-1510, 2012. PMID 22461103 (PMC Journal - In Process)
  79. Jepsen KJ, Andarawis-Puri N. The amount of periosteal apposition required to maintain bone strength during aging depends on adult bone morphology and tissue-modulus degradation rate. J Bone Miner Res, 27(9):1916-1926, 2012. PMID 22532507 (PMC Journal - In Process)
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  84. Schlecht SH, Jepsen KJ. Functional integration of skeletal traits: an intraskeletal assessment of bone size, mineralization and volume covariance. Bone 56:127–138, 2013
  85. Smith, L., Bigelow, E. M. and Jepsen, K. J. Systematic Evaluation of Skeletal Mechanical Function. Current Protocols in Mouse Biology. 3:39–67, 2013.
  86. Jepsen KJ, Schlecht SH, Kozloff KM. Are we taking full advantage of the growing number of pharmacological treatment options for osteoporosis? Current Opinion in Pharmacology 16:64-71, 2014.
  87. Jepsen KJ, Schlecht SH. Biomechanical mechanisms: resolving the apparent conundrum of why individuals with type II diabetes show increased fracture incidence despite having normal BMD. Journal of Bone and Mineral Research 29:784-786, 2014.
  88. Schlecht SH, Bigelow EMR, Jepsen KJ. Mapping the natural variation in whole bone stiffness across skeletal sites. Bone; 2014; 67:15-22.
  89. Khoury BM, Bigelow EMR, Smith LM, Schlecht SH, Scheller EL, Andarawis-Puri N, Jepsen KJ. The use of nano-computed tomography to enhance musculoskeletal research. Conn Tissue Res; 2014; early view, doi:10.3109/03008207.2015.1005211.
  90. Jepsen KJ, Bigelow EMR, Schlecht SH. Women build long bones with less cortical mass relative to body size and bone size compared with men. Clin Orthop Rel Res; 2015; early view, doi:10.1007/s11999-015-4184-2.
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